![]() This means they build the new strand in the 5′ to 3′ direction only. DNA polymerase can only bind to the 3′ end of a parental strand and work in one direction. ![]() DNA polymerase starts building at the 5’ end of the daughter strand.DNA polymerase “reads” the parental strand, and catalyses the addition of the free-floating nucleotides. DNA polymerase catalyses addition of free nucleotides.We previously established how in DNA, one strands goes from 3’ to 5’, and the opposite strand goes from 5’ to 3’.ĭNA polymerase Works in the 5′ to 3′ direction In a DNA double helix, the two strands are antiparallel.DNA ligase is responsible for the actual condensation reaction. These condensation reactions are catalysed by the enzyme DNA polymerase, which reads the nucleotides and enables them to join. To create a new strand of DNA, condensation reactions between these nucleotides need to occur in order to synthesise the daughter polynucleotide chain in order to complete DNA replication. The newly attracted nucleotides are only hydrogen bonded with the parental strand. Condensation reactions occur to complete DNA replication.Free floating nucleotides in the nucleus are attracted to these parental strands of DNA.ģ) DNA Polymerase (Condensation Reactions) The unwound strands of DNA are referred to as the parental strands. ![]() So each new DNA molecule is made up of one parent strand (see next point) from the original DNA molecule, and one new, daughter strand. The original strands of DNA act as a template for the synthesis of new strands of DNA. DNA gets unwound in one direction only, meaning the replication fork moves continuously in a unilateral direction.
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